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Counties: Henry County Henry County Area: 393 square miles Location: Eastern Indiana, bordered on the north by Delaware County, to the northeast by Randolph County, to the east by Wayne County, to the south by Fayette and Rush counties, and to the west by Hancock and Madison counties. Population: 48,508 (2000 Census) 1860 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 20,110 22,986 24,016 23,879 25,088 29,758 34,682 35,238 40,208 45,505 48,899 52,603 53,336 48,139 48,508 Cities & Towns: New Castle (county seat, 2000 population = 17,780); Middletown (2,488), Knightstown (2,148), Spiceland (807), Shirley (806), Kennard (455), Lewisville (395), Mooreland (393) Named For: Patrick Henry, Revolutionary War hero.